Procedures for the Use of BoneCure Membrane

Veterinarian surgeons in practice are able to diagnose the problem and perform any surgical procedures necessary to apply BoneCure Membrane. The specialists at RegeneCure are involved in the study of many conditions and techniques that are tested applying BoneCure Membranes which result in advances that can be shared with the Veterinary surgeon.

Please contact Dr. Michal (Michelle) Limor for consulting and getting assistance from RegeneCureā€™s veterinary surgeons in your planning of a surgery involving the use of the BoneCure Membrane.

The following procedures can be downloaded.

Contraindications and Precautions


Infection is a contra-indication for BoneCure as stated expressively also in the Instructions for Use.

Do not used BoneCure in cases of infection since the membrane will actually close in the infected area and augment its deleterious effects. The end result will be an infected foreign body which will have to be removed completely and a delayed or non-union of the the fracture.


In order to prevent post-operative infection of the surgical wound and the membrane, the veterinarian and owner should prevent external contamination from the dog's saliva (licking the wound), urine, feces or external dirt. This necessitates the maintenance of absolute hygiene and keep bandages dry and clean with frequent changes. Avoid such risk of infection during the first three weeks until the skin incision has healed completely.

In addition do not use BoneCure also in the following cases:

- History of malignancy, radiotherapy, or chemotherapy for malignancy
- Active autoimmune disease
- Any past or present immunosuppressive treatment
- Not indicated for use in load-bearing and unstable indications unless used in conjunction with appropriate fixation systems

Long Bone Fractures Femur Autograft Plate & Screws


Long Bone Fractures - Femur - Using Autologous Bone Graft or Bone Substitutes with Plate & Screws
Osteosynthesis with the use of BoneCure Membrane

Long Bone Fractures, Femur, Intramedullary Pin

BoneCure Membrane

Long Bone Fractures - Femur - Intramedullary Pin (IMP)
Osteosynthesis with the use of BoneCure Membrane

Carpal Arthrodesis

BoneCure Membrane

Carpal Arthrodesis
Osteosynthesis using BoneCure Membrane

Surgical approach to the cranial distal radius/ulna - carpal - metacarpal area

BoneCure Membrane - Instructions for Use ENGLISH

For Veterinary use only

Storage: Store the product at room temperature. Avoid excessive heat and humidity.
BoneCure Membrane is provided sterile for single patient use.

Membrane BoneCure - Mode d'emploi FRANCAIS

Usage reserve aux veterinaires uniquement

Conserver le produit temperature ambiante. Eviter les chaleurs fortes et l'humidite.
La membrane BoneCure est delivree sterilisee pour usage unique.

BoneCure Membran-Gebrauchsanweisung DEUTSCH

Nur fuer den Tieraerztlichen Gebrauch

Lagern Sie das Produkt bei Raumtemperatur. Vermeiden Sie uebermaessige Hitze und Feuchtigkeit.
BoneCure Membrane ist steril fuer den einmaligen Gebrauch.

Publications & Procedures

Press Releases:

July 8, 2013:

Reuters: RegeneCure Launches Implant for Pet Surgery, Eyes Human Market

Read more >>>>>>


June 4, 2013:

RegeneCure Starts Worldwide Veterinary Distribution of BoneCure Membrane Implant for Acceleration of Fracture Healing and Carpal Arthrodesis

Jerusalem, Israel, June 4, 2013 / B3C newswire / - RegeneCure Ltd., a  developer of novel regenerative membrane implant technology for the treatment of human and animal bone fractures,  announced today that the company has started to distribute its BoneCure® Membrane product to the veterinary market in Europa, the United States and Canada, Asia and Australia.

The use of the BoneCure Membrane for carpal arthrodesis is a major breakthrough in the surgery of companion animals that offers many advantages over the traditional “Gold Standard” procedure of harvesting an autogenous bone graft. This procedure, described at the BoneCure website, prevents patient morbidity and pain, reduces the risks of infection and fracture at the donor site, saves operating time and eliminates the need for a second incision.

Read more >>>>>>


March 12, 2013:

RegeneCure's Membrane Implant Shows 40% Accelerated Healing Time of Severe Bone Fractures in Pet Clinical Study

Jerusalem, Israel, March 12, 2013 / B3C newswire / RegeneCure announced today the successful results of a clinical study in pets using the company's regenerative membrane implant technology for the treatment of bone fractures. The study showed that the healing time was about 40 percent quicker than normally observed using current Standard of Care therapies. The product was also demonstrated to be safe in all of the study participants.

"The healing time for animals treated in the participating clinical study sites with injuries that normally take from five to twelve months was in many cases reduced to just eight weeks," said Dr. Michal Limor, VP Medical Affairs of RegeneCure.

The multi-center trial was conducted at leading veterinary clinics in England, Germany and Israel. The study included 35 mature dogs and cats with different bone fractures including delayed healing and non-union conditions.

Read more >>>>>>



In Vitro Study of a Novel Polymeric Mesenchymal Stem-Cell Coated Membrane

Ada Grin, Yoel Sasson, Shaul Beyth, Rami Mosheiff, Jacob Rachmilewitz, Michael Friedman

Journal of Drug Delivery Science Technology 19 (4) (2009): 241-246.

Abstract:   The objective of the study was to develop and study in vitro polymeric membrane that enables adhesion, proliferation, and differentiation of mesenchymal stem cells on its surface. We screened several membrane formulations with varying plasticizer types and concentrations for their ability to support MSC adherence and growth. To that end, MSCs were isolated from human bone marrow, and cell adherence to membrane, cell membrane interaction and cell morphology were observed using scanning electron microscopy (SEM) and fluorescent microscopy. MSCs adhered well to ammonio methacrylate copolymer type A (AMCA) membranes prepared with the various plasticizers and revealed spindle monolayer shape with podia, similar to polystyrene dishes. MSCs proliferated and differentiated only on AMCA membrane with polyethyleneglycol 400 (PEG400) as plasticizer. Furthermore, the membrane surfaces were characterized using SEM and their porosity was measured. These data confirm that MSCs maintain their stem cell traits after adhesion to membrane.

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